From the Airport:
Follow the signs to Boston through the Sumner Tunnel
Turn right and go up the entrance ramp - the sign will read Expressway North 93
Take the exit on the right which reads Back Bay/Storrow Drive
Stay in the right lane along the Charles River
Take the Copley Square exit on your left
Follow the exit to the end and turn right on Beacon Street
Go two blocks and turn left on Clarendon Street
Approximately five blocks further, turn right onto St. James Avenue
The Copley Plaza Hotel will be on your left

From Western Massachusetts and Points South via the Mass Pike:
Mass Pike (I-90) east to the Copley Square/Prudential Center, Exit 22
Follow the Copley Square exit and turn left at the first light onto Dartmouth Street
The Copley Plaza will be to your immediate right

From Points South Via I-95:
Follow I-95 north to I-93 North
Take the Mass Ave/Roxbury Exit 18
Follow ramp to Mass Ave.  Follow Mass Ave. one mile to Huntington Ave.
Turn right onto Huntington and follow 1/4 mile to Dartmouth Street.
Turn left on Dartmouth Street
The Copley Plaza Hotel will be immediately on your right.

From Points North via I-95:
Follow I-95 South to I-93 South
Take the Back Bay/Storrow Drive Exit 26
Follow Storrow Drive to the Copley Square exit
Turn right onto Beacon Street and then second left onto Clarendon Street
Approximately five blocks further turn right onto St. James Avenue
The Copley Plaza Hotel will be on your left